Renin inhibitory effect of N-Acetyl-Pepstatin
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چکیده
منابع مشابه
Pepstatin Inhibition of Human Renin
Pepstatin has been shown to be an extremely potent inhibitor of human renin (Ki = 1.3 X lo-lo M). Kinetic analyses by several techniques show reversible interaction of pepstatin with renin and classical noncofipetitive inhibition. The high affinity of pepstatin for renin allows kinetic determination of the molarity of the enzyme in partially purified preparations. This method has been validated...
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The reaction between hog renin and rat angiotensinogen followed Michaelis-Menten kinetics. A Km value of 1,109 ng angiotensin/ml was determined for the rate of angiotensin formation at pH 7.4 and 37°C. The pH optimum for the reaction of hog renin with rat angiotensinogen was between 6.8 and 7.0. Pepstatin inhibited the reaction in a noncompetitive way. The maximum inhibitory effect occurred at ...
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The direct effects of a renin inhibitor, N-acetyl-pepstatin and five angiotensin converting enzyme inhibitors, captopril and the active diacid forms of enalapril, ramipril, cilazapril, and CS-622, on the vascular renin-angiotensin system were examined in isolated perfused rat mesenteric arteries. Vascular renin activity and angiotensin II (Ang II) released into the perfusate were determined. In...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1978
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)67191-x